Addiction A-Z


MSIR is one of the brand names for the generic morphine sulfate. Available as both short-acting morphine and extended-release morphine, MSIR is used to treat moderate to severe pain.

MSIR should only be used to treat patients who are already being treated with a similar opioid pain medication and who is tolerant of its potent effects. When MSIR is swallowed, it is known to provide quick and effective pain relief. It is often used to treat breakthrough pain in cancer patients who have been receiving opioids on a regular basis to treat baseline pain.

MSIR is a Schedule II Controlled Substance and can easily be abused. It is not uncommon for MSIR to be diverted for non-medical use, especially in combinations with other psychoactive substances. It works to relieve pain by activating certain receptors in the brain that cause pain relief. As an opiate painkiller, it is the strongest painkiller known to man.

MSIR has the ability to create adverse reactions in patients, even if they are taking the medication for medical purposes. On the minor side, effects can include anxiety, constipation, depressed or irritable mood, dizziness, drowsiness, exaggerated sense of well-being, light-headedness, sedation, sweating and vomiting.

More serious reactions can also be present with use and they include respiratory depression, respiratory arrest, apnea, circulatory depression, cardiac arrest, hypotension and/or shock. Without proper monitoring, MSIR can be life-threatening, especially is an individual happens to overdose on the medication.

MSIR taken over a long period of time can not only be damaging to the body, it can also cause tolerance, dependence and addiction. When an individual stops taking MSIR, they are likely to experience some degree of narcotic withdrawal syndrome. Within 24 hours an individual can experience dilated eyes, goose bumps, restlessness, restless sleep, runny nose, sweating, tearing or yawning.

Any and all of the following symptoms can occur in the MSIR withdrawal stage over the next 72 hours:

  • Abdominal and leg pains
  • Abdominal and muscle cramps
  • Anxiety
  • Diarrhea
  • Hot and cold flashes
  • Inability to fall or stay asleep
  • Increase in body temperature
  • Increase in blood pressure
  • Increased breathing and heart rate
  • Loss of appetite
  • Nasal discharge
  • Nausea and vomiting
  • Severe backache
  • Twitching
  • Spasm of muscles
  • Weakness

As MSIR is the most powerful painkiller known to man, it can also be the most dangerous. When a person takes the medication for a long period of time, in large doses or for recreational purposes, dependence can arise that can be very difficult to eliminate. The mental and physical addiction likely to occur makes it very difficult to stop taking the drug or to function normally without it as the withdrawal stage is very difficult.

As a result, detoxification is required to cleanse the body of this drug and must be done under the care of a board-certified physician and a board-certified psychiatrist.

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